Endocrine Abstracts

Annexin A1 - a unique mediator of glucocorticoid action.Annexin A1 is a 37 KD protein found in a variety of differentiated cell types in the mammalian body. It is a member of a super family of proteins known as the annexins of which approximately 13 are found in mammals. Annexin A1 is one of the most studied members of this family and appears to play a key role in mediating the effects of glucocorticoid hormones and drugs on the immune and neuro-endocrin...

There is evidence from human studies that dehydroepiandrosterone (DHEA) may regulate acquired immunity by promoting a shift towards a T helper type 1 (Th1) phenotype and in innate immunity by suppression of inflammation. Interestingly, circulating levels of DHEA/DHEA-S are significantly reduced in patients with rheumatoid arthritis and systemic lupus erythematosis and are also negatively correlated with age.Annexin 1 (ANXA1) is a glucocorticoid-induced p...

Immunoneutralisation and antisense studies have shown that the acute regulatory actions of glucocorticoids (GCs) on the secretion of corticotrophin (ACTH) from the anterior pituitary gland are dependent upon the 37 kDa protein, annexin 1 (Anxa1 [1]), which is localised mainly to the S100-positive folliculo-stellate (FS) cells that lie in close apposition with the endocrine cells. The aim of this study was to examine pituitary function in male and female mice lacking the Anxa1 ...

Our previous studies have shown that the acute regulatory actions of glucocorticoids (GCs) on the secretion of corticotrophin (ACTH) are dependent upon the translocation of a 37 kDa protein, annexin 1 (ANXA1 [1]) from within the cell to the outer cell surface where it is retained by a Ca2+-dependent mechanism (2). The mechanisms by which ANXA1 is exported from pituitary cells in response to a steroid challenge and acts on the endocrine cells to suppress peptide rele...

There is now substantial evidence to suggest that the early life environment can have a permanent effect on adult physiology. Recently we have shown that early postnatal glucocorticoid (GC) exposure produces alterations in midbrain dopaminergic cell number in the adult rat, in a gender-specific manner (McArthur et al., Brit. Neurosci. Assoc. Abstr. 2003;17:27). Since the protein annexin 1 (ANXA1) mediates some aspects of the effects of GCs within the immune system and the hypo...